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Coca leaf in Bolivia Indigenous peoples of South The united states have chewed the leaves of Erythroxylon coca—a plant which contains essential nutrients together with many alkaloids, such as copyright—for over a thousand yrs.[165] The coca leaf was, and continue to is, chewed Nearly universally by some indigenous communities.

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while in the early nineties, Peru and Bolivia have been the primary places for converting coca leaf to coca paste and copyright base, although Colombia was the primary place for the final conversion for these solutions into copyright hydrochloride

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The biosynthesis in the tropane alkaloid continues to be not comprehended. Hemscheidt proposes that Robinson's acetonedicarboxylate emerges as a possible intermediate for this reaction.

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